Allogeneic Allograft
June 26, 2026
Barbotage
August 25, 2020Urogenital Regenerative Medicine For Men
PRP
PRP stands for Platelet Rich Plasma. Platelet rich plasma is made from a fresh sample of your own blood. The sample is specially prepared to separate out, concentrate and then stimulate the platelets, which then are injected.
Platelets are powerful particles in the blood that normally concentrate at an area of injury and set off a signaling cascade that tells the body to heal or rejuvenate a damaged area. Some of the powerful signaling molecules that platelets make include Platelet-Derived Growth Factor (PDGF) – Responsible for cell growth and division, Vascular Endothelial Growth Factor (VEGF) – Responsible for creation of new blood vessels and capillaries, Transforming Growth Factor (TGF) – Controls cell growth and cell differentiation, and Epidermal Growth Factor (EGF): –Regulating cell growth and differentiation.
While platelet dose remains an important factor, emerging research suggests that the biological activity of a PRP preparation may also depend on how the product is processed, activated, filtered, and delivered.
For patients considering PRP or other Orthobiologic treatments, not all PRP preparations are created equal.
By optimizing growth factor signaling, timing, and concentrating beneficial plasma proteins and autologous exosomes, the next generation of PRP available at Hawaii Island Regenerative medicine and Stem Cell Therapy goes beyond our competitors to target the body’s natural repair and regrowth processes in a more biologically sophisticated manner.
Read the full details about our next generation PRP therapy here.
For those who wish to take advantage of the accumulating evidence, Platelet Rich Plasma injection into the penis may demonstrate dramatic and permanent improvements in sexual function, including enhancing size, girth, sensitivity, erectile function and even ejaculation control This therapy can also be used to treat diseases of the penis such as erectile dysfunction, Pyronine’s disease, and Lichen planus.
Allogeneic Allograft
An allogeneic allograft is regenerative tissue donated from another individual that is applied to diseased or chronically injured tissues in the recipient.
In both the laboratory and in small scale clinical trials to date, these products have been shown to be uniquely helpful in regeneration of chronically diseased tissues. These birth products are a purified portion of the umbilical cord, also known as the Whartons Jelly, and although not intended to provide signaling effects due to FDA regulations, and while no claims can be made as to live cell activity, these products are generally thought to contain live Mesenchymal Stem Cells (MSC’s) live Exosomes (Extracellular Signaling Vesicles) and Polypeptide Enriched Matrix (PEM).
MSC’s are thought to exert their effects through paracrine signaling, that is, the release of signaling factors to communicate with the surrounding cells and cellular environment in favor of regeneration and repair. In large part, they mediate this signaling effect through exosomes, which are small spherical membrane structures that are released from mesenchymal stem cells to circulate in the extracellular space. These spherical membranes are packages containing signaling material, protein, and mRNA, which can turn on genes and genomic proteins of growth and repair in the target tissue, and modulate the immune response in order to reduce inflammation. And finally, the polypeptide enriched matrix (PEM) (extracellular) component of the Whartons jelly, contains the growth media and structural support for the entire system, containing growth factors, peptides, and hyaluronic acid, to name a few.
These biological materials are thought to:
- Improve firmness through Stimulate collagen and elastin production
- Improve sensitivity
- Improve erectile function through improvement to circulation
- Improve ejaculation control
- Improve disease of the penis such as peyronies disease and lichen planus